|
KMID : 0381920080380020081
|
|
Korean Journal of Microscopy
2008 Volume.38 No. 2 p.81 ~ p.87
|
|
|
The Effect of Mineral-induced Alkaline Reduced Water on the DSS-induced Acute Inflammatory Bowel Disease Mouse Model
|
|
Jin Dan
Kim Dong-Heui
Teng Yung-Chien
Qi Xu-Feng
Lee Kyu-Jae
|
|
|
Abstract
|
|
|
Alkaline reduced water (ARW) has been used for drinking widely in several countries of Asia. The safety and clinical
effects of ARW has been reported including anti-oxidative effect and intestinal abnormal fermentation. To confirm the
effect of ARW on DSS-induced acute inflammatory bowel disease (IBD) mouse model, we observed the length of total
large intestine and the histopathological changes after supplying mineral induced-ARW (MARW) for 2 weeks and oral
administration of 4% DSS (dextran sulfate sodium).
As the result, the length of total large intestine and the disease scores by macro and microscopical access in the ARWsupplied group showed no significant differences compared with those in the control group. This result suggests that the supply of ARW for 2 weeks exerted no effect on amelioration in the DSS-induced acute IBD model. However, in
consideration of the effect of ARW on the improvement of intestinal environment and gastrointestinal disease, this result
seems that acute IBD animal model is not suitable or the period of ARW supply is not enough to prove the effect of
ARW. The ameliorative effect of ARW on the intestinal abnormal fermentation has been confirmed by some researchers,
but the precise mechanism also remain unclear. In conclusion, although MARW had no effect on the DSS-induced acute
experimental colitis model, further studies on the verification of the effects of ARW by using other intestinal disease
model and by long-term supply of ARW will be required. Also, It needs to clear the mechanism of ARW on the intestinal
environment.
|
|
|
KEYWORD
|
|
|
Alkaline reduced water (ARW), Inflammatory Bowel Disease (IBD), Dextran sulfate sodium (DSS), Mouse
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|